Zoloft box

Zoloft tablets

Generic Name: Sertraline
Brands Names: Zoloft

Price Range: $0.37 – $0.68
Dosage: 100mg / 50mg / 25mg

What is Zoloft?

Zoloft is a third-generation antidepressant, widely used in medical practice, which prevents the involvement of serotonin and, thus, increases its concentration and effectiveness. The drug acts mainly on the central nervous system.

Composition and form of release

Produced in the form of white oblong tablets with engraving on one side and indicating concentration on the other.
One tablet contains 0.05 or 0.1 g of sertraline. Auxiliary substances are starch, magnesium stearate, titanium dioxide, polysorbate, macrogol, calcium dihydrogen phosphate.

The active substance of Zoloft is sertraline, which has a pronounced antidepressant effect. It prevents the inverse capture of serotonin by neurons, increasing the amount of serotonin. Thus, sertraline eliminates depressive conditions caused by a serotonin deficiency. The effect of sertraline is to correct bad mood, eliminate sadness, anxiety, phobias, and fears, increase appetite associated with these conditions. It has a slight analgesic and sedative effect.

Due to the fact that the drug does not have adrenergic and dopaminergic effects, it is well tolerated by elderly patients. With prolonged treatment at the correct dosage, Zoloft is not able to cause addiction or influence weight gain.

When you take Zoloft during meals it increases the absorption of the drug by about a quarter, increases the speed of action and the achievement of maximum concentration. Zoloft begins to act four to five hours after taking the pill. Digestibility in adolescents and elderly people is not significantly different.

Indications for use

Zoloft is prescribed for depression of various origins, with anxiety-depressive states, insomnia, phobias, panic disorder, obsessive-compulsive neurosis. It is intended to treat and prevent posttraumatic psychiatric and sensory disorders, with a pronounced social phobia.

Zoloft is taken orally, once a day. Admission is not dependent on food, but when the pill taken during meals, is able to act faster. The initial dosage for obsessive-compulsive neurosis and depression is minimal, not more than a tablet. In case of panic disorder and social phobia, the dosage should be half that. Increase in dosage is carried out a week after the start of taking with normal tolerability of the drug.

If the necessary therapeutic effect is not achieved, the dosage is increased but not often than once a week. The maximum daily dosage should not exceed 0.2 g per day. The first therapeutic effects are achieved during the first week of treatment. A full evaluation of the effectiveness of therapy is possible during the first month of treatment.

To maintain the patient’s condition after treatment, Zoloft is prescribed in minimum effective dosage, adjusting it once a week, depending on how well the drug is transferred. Zoloft shows proven effectiveness in treating obsessive-compulsive neurosis in children from six to seventeen years of age. Treatment begins with minimal dosage, increasing it a week after the start of the treatment.

Therapeutic efficacy of the drug in the treatment of depressive states and anxiety in adolescents is similar to treatment in adults. But it should be borne in mind that adolescents and children have a lower body weight than adult patients, especially if the dosage is more than 0.05 g per day.

In the treatment of elderly patients, dosage adjustment is not required. In patients with liver dysfunction, the drug should be used with caution, in small doses. If the kidneys are not functioning properly, dosage adjustment is also not required, but the creatinine clearance must be checked periodically.

Contraindications

It is not prescribed for intolerance to sertraline, it is not used in pediatrics, for treatment of children under six years of age. Contraindicated in the use of patients undergoing therapy with drugs that inhibit monoamine oxidase.
The drug should be used with caution for organic lesions of the brain, with mental retardation, epileptic seizures, insufficiency of hepatic and renal function, and anorexia.

There were no full-fledged studies about the effect of Zoloft in pregnancy and fetal status that’s why the drug is prescribed only when the doctor decides about the inevitability of sertraline treatment.

The drug penetrates into breast milk, so during lactation is not prescribed to prevent effects on the fetus.

Side effects

There may be side effects such as flatulence, nausea, up to vomiting, and diarrhea. There are also possible pains in the intestines and stomach, unpleasant aftertaste in the mouth. In rare cases, pancreatitis developed. There may be arrhythmia, tachycardia, hypertension and muscle cramps, arthralgia.
The central nervous system can respond with a lack of confidence in the arrival, gnashing of teeth at night, involuntary contraction of the muscles. Among the side effects, nightmarish dreams, psychosis, states of euphoria, mania, anxiety, insomnia were also noted.

Also, such side effects may occur like violation of the outflow of urine, decrease in libido, delay in ejaculation, problems with the menstrual cycle. Among the side effects of the endocrine system, hypothyroidism, hyperprolactinemia, is noted. Its is possible development of liver failure, jaundice, drug-induced hepatitis.

With a sharp reduction in dosages of Zoloft in rare cases, there is a risk of developing drug withdrawal. Zoloft cancellation syndrome is manifested by depressiveness, auditory and visual hallucinations, aggressive behavior, insomnia including possible psychosis and anxiety.

Symptoms and treatment of an overdose

Even with the appointment of high dosages, overdoses were very rare. But the simultaneous reception of Zoloft and alcohol can lead to severe intoxication, coma, and fatalities. Zoloft is not prescribed simultaneously with drugs that inhibit monoamine oxidase. When treating this group of drugs, you need to withstand two weeks before start treatment with Zoloft.

In the treatment of Zoloft, it is necessary to constant monitoring of patients for the development of the neuroleptic syndrome. Zoloft and alcohol are categorically incompatible since they can cause a sudden change in vital functions.
In the treatment of patients taking drugs with anti-aggregation action, the combination with other drugs may cause dizziness and impaired consciousness, so you should refrain from driving the car.

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